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Each combination underscores the necessity of professional medical oversight to balance benefits against amplified risks, ensuring that polypharmacy serves a clear therapeutic purpose without introducing new, uncontrolled hazards. The question of combining modafinil with antidepressants is a significant one, as both classes of drugs exert powerful influences on the central nervous system. More serious but rare risks include severe dermatological reactions (like Stevens-Johnson Syndrome), psychiatric symptoms such as anxiety, mania, or hallucinations in susceptible individuals, and potential for dependency (though the risk is considered lower than for Schedule II stimulants).
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