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Indicated for: Epilepsy (Lennox-Gastaut Syndrome, Akinetic Seizures, Myoclonic Seizures, Absence Seizures, Focal Seizures, Infantile Spasms), Panic Disorder with or without Agoraphobia, Generalized Anxiety Disorder (Short-term Adjunctive Therapy), Restless Legs Syndrome (Refractory), Rapid Eye Movement Sleep Behavior Disorder, Acute Mania (Adjunctive), Neuroleptic-Induced Akathisia, Acute Alcohol Withdrawal Syndrome, Sleep Bruxism, Trigeminal Neuralgia (Off-label Adjunctive), Stiff Person Syndrome.
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This divided schedule ensures a smooth, continuous level of anxiolytic coverage throughout the waking hours, when the patient is most vulnerable to panic triggers and the stresses of daily life, while the evening dose helps to quiet the mind and facilitate the transition into a restful and restorative sleep, free from the intrusion of nocturnal anxiety or panic awakenings. These are not rare or idiosyncratic side effects; they are the direct, predictable, and dose-dependent pharmacologic consequences of enhancing central GABAergic tone. The experience of profound sleepiness, or somnolence, is the single most predictable and prominent pharmacologic effect of a 2 mg dose of Klonopin in the benzodiazepine-naïve individual, and it is an expected, and often therapeutically intended, outcome in patients who are appropriately prescribed this dose for the management of specific, severe sleep disorders.
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